Orgasteron (normethandrolone)

Normethandrolone is a potent oral derivative of nandrolone, which was sold by the international drug firm Organon decades ago. Organon had marketed it under the Orgasterone brand name in Belgium and Switzerland,and as Orga-steron in the Netherlands. This steroid had also been sold by other manufacturers in various parts of Europe as Methalutin, Lutenin,and Matdonal. Normethandrolone first appeared in the medical journals during the 1950's, where it was being researched for a variety of uses including the treatment of painful menstruation in women. Despite having many potential clinical uses (though perhaps uses that are not unique to this steroid), this agent did not last long on the global drug market. Organon and other manufacturers began discontinuing its sale not very long after market introduction, and today this steroid is all but a vague memory amongst bodybuilders.

This steroid is relatively simple in a structural sense, which is probably no surprise given how early it was created in the history of steroids. Normethandrolone, which may also be called methylnandrolone or methylnortestosterone, can crudely be looked at as the "methyltestosterone of Deca" It differs from its parent hormone nandrolone only by the addition of c-17 alpha alkylation,the same alteration that separates methyltestosterone from testosterone.This, of course, was added to make oral dosing viable, a job which it does very efficiently. Studies looking at the oral potency of this steroid rate it to be roughly 3-6 times more anabolic than methyltestosterone, while possessing only roughly 10-25% more androgenicity. The overall anabolic-androgenic ratio of this steroid falls somewhere between 3:1 and 5.5:1, which is a considerable separation. In this case, methylation seems to have accomplished exactly what it was expected to. The relative character of the steroid (in an anabolic/androgenic sense) is loosely retained, and the agent may be effectively administered as an oral where it could not before.

Although it is effective orally, normethandrolone is not the most idea steroid for bodybuilders, at least where lean mass is concerned (something Deca is highly favored for). Like methyltestosterone, this drug is a good example of an early steroid that looks relatively crude next to later advancement in the field. One reason is the effect 17-alpha methylation has on the progestational nature of nandrolone. Nandrolone already has progestational activity, a side of this steroid that can sometimes make it problematic (progestins can exacerbate,sometimes mimic, the side effects of estrogens). When we add a c-17 methyl group to nandrolone, progesterone receptor binding is significantly enhanced. In fact, it was assayed to be more active of a progestin than progesterone. Some early studies even refer to this agent as a progestogenic (progestational) compound with anabolic action, not directly as an anabolic/androgenic steroid. In effect, we are beginning to see the same thing we do when we methylate testosterone; potency and side effect potential both seem to be enhanced.

To make things a little bit worse, nandrolone also aromatizes. This occurs at a much slower rate than we see with testosterone, so this tendency of Deca's usually isn't much of a problem for the average user. However, it is still there. Once we methylate nandrolone, this characteristic starts to come out with more ferocity. The rate of aromatization is actually reduced with c-17 alpha alkylated steroids, but the more potent estrogen 17a- methylestradiol is produced. Methylestradiol is more active than regular estradiol because it resists metabolism and exists in a more free state (less binding to serum proteins). So even though we have less estrogen, we get far more estrogenicity. It took me a good deal of time to research and explain this tendency among methylated steroids. I knew the same type of situation occurred with boldenone, and it bugged me for years. Just for reference, boldenone (which doesn't produce much estrogen either) becomes the notably estrogenic steroid Dianabol when methylated. Dianabol is tolerable, but still nothing like boldenone. Combine the strong progestational nature of normethandrolone with aromatization to methylestradiol, and we have a decently estrogenic agent (perhaps one that you would not find tolerable). At the very least, expect the use of this agent will be accompanied by water and fat retention, and even gynecomastia if you are sensitive to it.

Being a fairly potent compound, normethandrolone should be effective in comparatively small doses. This would land somewhere between 5mg and 20mg per day (men), depending on the use of other compounds and/or desired results. Women can get by on much less, of course, perhaps beginning with only 1-2mg daily.This compound should probably be used exclusively for bulking phases or training, as its progestational and estrogenic nature will undoubtedly work against fat loss and muscle definition when trying to cut. Used alone, one can expect to see decent gains, something perhaps in line with a Dianabol cycle (but with a seemingly more noteworthy estrogenic side to it). Again, related side effects such as increased fat gain and bloating are likely, and can be reduced with concurrent use of an anti-estrogen such as Nolvadex or Clomid. Hepatotoxicity should always be a concern with use, and for this reason cycles should be kept limited in length (perhaps 6-8 weeks). Jaundice (bile duct obstruction) was reported as early as 1958 with this steroid be safe, it would be good advice to get your liver enzymes done at least once or twice while using.

Much of the information presented here is going to be of little practical value to the average reader, as Orgasteron is long gone now and no commercial preparations containing normethandrolone are known to exist. Still, we are in the age of the global steroid community, designer steroids, and obscure research chemicals. I know normethandrolone is being synthesized overseas, and undoubtedly is circulating in the U.S. in small amounts. Perhaps in the future we will even see underground or veterinary versions of the drug. Should you find access in any form, make sure you treat this steroid with the same legal care that you would other illegal steroid products. Despite never being commercially sold in the U.S., normethandrolone was added to the controlled substances laws in 2004 as a Schedule III anabolic steroid. As such, possession, even for "research purposes" is now illegal without a DEA license. It is not available by prescription either, so possession will be very difficult to defend. Given that this is still a relatively "crude" steroid with virtually no demand for it, I don't expect we will see a big future for it on the black market. But anything is possible. 

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